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Name of Protein

Potassium channel tetramerization domain-containing 15

Protein Function

Year Discovered

Regulates neural crest formation| implicated in adipogenesis



Potassium Channel Tetramerization Domain-Containing 15 (KCTD15) is a protein-coding gene that plays a significant role in various biological processes. This protein is a member of the potassium channel tetramerization domain-containing (KCTD) family, characterized by the presence of a T1 domain involved in the assembly and regulation of potassium channels. The KCTD family has a diverse range of functions, including the regulation of ion channels, protein-protein interactions, and cellular processes such as signal transduction, cell proliferation, and apoptosis.KCTD15 is known to participate in protein-protein interactions and contributes to the assembly and regulation of potassium channels. Potassium channels are essential for maintaining the resting membrane potential and controlling the electrical excitability of cells. They play a critical role in the regulation of various physiological processes, such as muscle contraction, nerve signaling, and the release of hormones.Tetramerization of potassium channels is a fundamental aspect of their function, as the channels are composed of four subunits that come together to form a functional ion-conducting pore. The T1 domain found in KCTD15 is responsible for mediating this tetramerization process. By interacting with the T1 domains of other potassium channel subunits, KCTD15 helps assemble the tetrameric structure necessary for the proper function of these channels.While the precise role of KCTD15 in potassium channel regulation is still being elucidated, research has demonstrated its involvement in modulating channel gating, expression, and trafficking. Through these mechanisms, KCTD15 can impact the electrical properties of cells and influence a range of physiological processes.In addition to its role in potassium channel regulation, KCTD15 has been implicated in other cellular processes. For example, it has been found to interact with neural precursor cell-expressed, developmentally down-regulated 4-2 (NEDD4-2), an E3 ubiquitin-protein ligase. This interaction suggests a potential role for KCTD15 in the regulation of protein degradation and turnover.Furthermore, KCTD15 has been implicated in the regulation of adipogenesis, the process by which fat cells (adipocytes) differentiate and mature. Studies have shown that KCTD15 can negatively regulate adipogenesis by interacting with the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ), which is essential for adipocyte differentiation. By inhibiting PPARγ activity, KCTD15 may play a role in preventing excessive fat accumulation and maintaining metabolic homeostasis.Interestingly, genetic variations in the KCTD15 gene have been associated with obesity in humans. Single nucleotide polymorphisms (SNPs) within the KCTD15 gene have been identified as potential risk factors for obesity, suggesting that alterations in KCTD15 function could contribute to the development of this complex metabolic disorder.In summary, KCTD15 is a multifunctional protein that plays a crucial role in the assembly and regulation of potassium channels, as well as other cellular processes such as protein degradation and adipogenesis. Its involvement in these diverse biological functions highlights the importance of understanding the molecular mechanisms by which KCTD15 exerts its effects. Further research into the role of KCTD15 in health and disease may provide new insights into the regulation of potassium channels and offer novel therapeutic targets for a variety of medical conditions, including obesity and other metabolic disorders.

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