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Name of Protein

Bone morphogenetic protein 8B

Protein Function

Year Discovered

Regulates energy expenditure and thermogenesis



Bone morphogenetic protein 8B (BMP8B) is a member of the BMP family, which belongs to the transforming growth factor-beta (TGF-β) superfamily of proteins. These proteins play crucial roles in various physiological processes, including cell differentiation, proliferation, and development. BMP8B is predominantly expressed in reproductive tissues, such as the testis and ovary, but has also been found in brown adipose tissue (BAT). Recent studies have demonstrated that BMP8B is involved in the regulation of energy homeostasis and thermogenesis. In BAT, BMP8B enhances the thermogenic capacity by increasing the expression of uncoupling protein 1 (UCP1), promoting energy expenditure and heat production. BMP8B may thus represent a potential therapeutic target for obesity and metabolic disorders.

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