Name of Protein
Adiponectin receptor 2
Regulates glucose and lipid metabolism in response to adiponectin
Adiponectin receptor 2 (AdipoR2) is a cell surface receptor protein involved in regulating energy metabolism, insulin sensitivity, and inflammation. It is one of the two known receptors for adiponectin, an adipocyte-derived hormone with pleiotropic effects on various physiological processes. AdipoR2 is predominantly expressed in the liver, but can also be found in other tissues, such as skeletal muscle and adipose tissue.Adiponectin plays a crucial role in maintaining metabolic homeostasis by regulating glucose and lipid metabolism, promoting insulin sensitivity, and exerting anti-inflammatory effects. It achieves these functions by binding to its receptors, AdipoR1 and AdipoR2, thereby activating a series of intracellular signaling pathways.Upon binding of adiponectin to AdipoR2, the receptor activates the peroxisome proliferator-activated receptor alpha (PPARα) pathway. PPARα is a nuclear receptor that regulates the expression of genes involved in lipid metabolism, fatty acid oxidation, and inflammation. Activation of the PPARα pathway by AdipoR2 leads to improved lipid metabolism, enhanced insulin sensitivity, and reduced inflammation, all of which contribute to the maintenance of metabolic homeostasis.Dysregulation of AdipoR2 function has been associated with various metabolic disorders, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Reduced expression or altered function of AdipoR2 may contribute to the development of insulin resistance and inflammation, key features of these disorders. Therefore, targeting AdipoR2 and its downstream signaling pathways may provide novel therapeutic strategies for the prevention and treatment of metabolic diseases.In summary, adiponectin receptor 2 (AdipoR2) is a cell surface receptor protein involved in regulating energy metabolism, insulin sensitivity, and inflammation through its interaction with adiponectin. Its role in activating the PPARα pathway is essential for maintaining metabolic homeostasis. Dysregulation of AdipoR2 function may contribute to the development of metabolic disorders, making it a potential therapeutic target for obesity, type 2 diabetes, and NAFLD.