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GLP-1 Agonists

GLP-1 Agonists: GLP-1 agonists, such as liraglutide (Saxenda), are medications originally developed for diabetes but also approved for weight loss. They work by mimicking the effects of the hormone glucagon-like peptide-1, increasing satiety and delaying gastric emptying. Side effects include nausea, vomiting, and diarrhea. Saxenda is available by prescription in the US.

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Era of Discovery

2010s

Mechanism of Action

Mimic the effects of glucagon-like peptide-1, increasing satiety and delaying gastric emptying

History of Use in the United States

Approved for weight loss (e.g., liraglutide/Saxenda)

Benefit of Weight Loss Agent or Medication

Weight loss due to increased satiety and delayed gastric emptying

Possible Side Effects

Nausea, vomiting, diarrhea

Current Regulatory Status in US

Available by prescription (e.g., Saxenda)

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