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GLP-1 Agonists

GLP-1 Agonists: GLP-1 agonists, such as liraglutide (Saxenda), are medications originally developed for diabetes but also approved for weight loss. They work by mimicking the effects of the hormone glucagon-like peptide-1, increasing satiety and delaying gastric emptying. Side effects include nausea, vomiting, and diarrhea. Saxenda is available by prescription in the US.

Era of Discovery

2010s

Mechanism of Action

Mimic the effects of glucagon-like peptide-1, increasing satiety and delaying gastric emptying

History of Use in the United States

Approved for weight loss (e.g., liraglutide/Saxenda)

Benefit of Weight Loss Agent or Medication

Weight loss due to increased satiety and delayed gastric emptying

Possible Side Effects

Nausea, vomiting, diarrhea

Current Regulatory Status in US

Available by prescription (e.g., Saxenda)

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This website is intended to provide information about medical weight loss. However, no information presented here should be construed as medical advice. This website is for informational and educational purposes only. Before starting any weight loss program, it is important to consult with your health care provider to ensure the program is safe and appropriate for you. Your health care provider can provide personalized guidance, advice, and support to help you reach your weight loss goals. If you choose Dr. Holland as your provider, you should only follow the advice he gives you personally during your meetings with him and if you are uncertain about your care you should contact Holland Clinic and not rely on this website.

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Holland Clinic
Medical Weight Loss Program
Mark J. Holland MD
2440 Louisiana NE, Suite 540
Albuquerque, New Mexico  87110
(505) 232-6818
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