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Name of Protein

Angiopoietin-like 4

Protein Function

Year Discovered

Regulates lipid metabolism and energy homeostasis



Angiopoietin-like 4 (ANGPTL4) is a secreted protein that plays a crucial role in regulating lipid metabolism, angiogenesis, and inflammation. It is a member of the angiopoietin-like protein family, which shares structural similarities with the angiopoietin family of proteins involved in blood vessel formation. ANGPTL4 is expressed in various tissues, including adipose tissue, liver, and skeletal muscle, and is responsive to metabolic, hormonal, and nutritional cues.In lipid metabolism, ANGPTL4 functions as a potent inhibitor of lipoprotein lipase (LPL), an enzyme responsible for the hydrolysis of triglycerides in circulating lipoproteins to release free fatty acids. By inhibiting LPL activity, ANGPTL4 controls the availability of free fatty acids for uptake and utilization by various tissues. This regulation has a significant impact on energy homeostasis, as it affects the balance between fatty acid storage in adipose tissue and fatty acid oxidation in other tissues, such as the liver and skeletal muscle.ANGPTL4 has also been implicated in the regulation of angiogenesis and inflammation. It has been shown to modulate endothelial cell function and blood vessel formation, as well as to influence the activation of immune cells and the production of inflammatory mediators.Dysregulation of ANGPTL4 expression or function has been associated with various metabolic disorders, including obesity, insulin resistance, and dyslipidemia. Altered ANGPTL4 levels may contribute to imbalances in lipid metabolism and the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in arterial walls. Consequently, targeting ANGPTL4 and its downstream pathways has emerged as a potential therapeutic strategy for the treatment of metabolic diseases and related complications.In summary, angiopoietin-like 4 (ANGPTL4) is a secreted protein involved in the regulation of lipid metabolism, angiogenesis, and inflammation. Its role in modulating lipoprotein lipase activity and lipid homeostasis has significant implications for energy balance and the development of metabolic disorders. Dysregulation of ANGPTL4 expression or function may contribute to obesity, insulin resistance, and dyslipidemia, making it a potential target for therapeutic interventions aimed at treating these conditions.

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