Drug Classes That Cause Obesity

Though it is mentioned surprisingly little, many over-the-counter and prescription medications cause weight gain. Some of them cause massive weight gain. These 'obesigenic' medications are so common that nearly every American has been exposed to them and many of us take them regularly. It is not my intention here to cause panic and it is certainly not my intention to cause a reader to stop taking a necessary medication. Rather, I simply want to make people aware that there really are a lot of drugs that can make you fat.

List of Drug Class Combinations Known to Cause Weight Gain-From the National Drug Code Database (NDC) of the U.S. FDA

Serotonin Reuptake Inhibitor [EPC],Serotonin Uptake Inhibitors [MoA]| WEIGHT GAIN
Serotonin Reuptake Inhibitor [EPC],Serotonin Uptake Inhibitors [MoA],Atypical Antipsychotic [EPC]| WEIGHT GAIN
Atypical Antipsychotic [EPC],Serotonin Reuptake Inhibitor [EPC],Serotonin Uptake Inhibitors [MoA]| WEIGHT GAIN
Atypical Antipsychotic [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]| WEIGHT GAIN
Anti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE],Mood Stabilizer [EPC]| WEIGHT GAIN
Angiotensin Converting Enzyme Inhibitor [EPC],Angiotensin-converting Enzyme Inhibitors [MoA],Calcium Channel Antagonists [MoA],Calcium Channel Blocker [EPC]| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Angiotensin Converting Enzyme Inhibitor [EPC],Angiotensin-converting Enzyme Inhibitors [MoA],Decreased Blood Pressure [PE]| WEIGHT GAIN
Benzodiazepine [EPC],Benzodiazepines [Chemical/Ingredient]| WEIGHT GAIN
Carbonic Anhydrase Inhibitor [EPC],Carbonic Anhydrase Inhibitors [MoA],Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Adrenergic alpha-Antagonists [MoA],Adrenergic beta1-Antagonists [MoA],Adrenergic beta2-Antagonists [MoA],alpha-Adrenergic Blocker [EPC],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA]| WEIGHT GAIN
Sulfonylurea [EPC],Sulfonylurea Compounds [Chemical/Ingredient]| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC]| WEIGHT GAIN
Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient]| WEIGHT GAIN
Cytochrome P450 1A2 Inducers [MoA],Cytochrome P450 2B6 Inducers [MoA],Cytochrome P450 2C9 Inducers [MoA],Cytochrome P450 2C19 Inducers [MoA],Anti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE],Mood Stabilizer| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides| WEIGHT GAIN
Renin Inhibitor [EPC],Renin Inhibitors [MoA],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient]| WEIGHT GAIN
Renin Inhibitor [EPC],Renin Inhibitors [MoA],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Corticosteroid Hormone Receptor Agonists [MoA]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC],Adrenergic alpha-Agonists [MoA],alpha-Adrenergic Agonist [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Sulfonamide Antibacterial [EPC],Sulfonamides [Chemical/Ingredient]| WEIGHT GAIN
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Adrenergic Agonists [MoA],Adrenergic Receptor Agonist [EPC],Decreased Histamine Release [PE],Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Inhibitor [EPC]| WEIGHT GAIN
Adrenergic alpha-Agonists [MoA],alpha-Adrenergic Agonist [EPC],Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC]| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Calcium Channel Blocker [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC]| WEIGHT GAIN
Anti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE]| WEIGHT GAIN
Cannabinoid [EPC],Cannabinoids [Chemical/Ingredient]| WEIGHT GAIN
Centrally-mediated Muscle Relaxation [PE],Muscle Relaxant [EPC]| WEIGHT GAIN
Antiemetic [EPC],Emesis Suppression [PE]| WEIGHT GAIN
Antihistamine [EPC],Histamine Receptor Antagonists [MoA]| WEIGHT GAIN
Mood Stabilizer [EPC]| WEIGHT GAIN
gamma-Aminobutyric Acid A Receptor Agonist [EPC],GABA A Agonists [MoA],Central Nervous System Depression [PE]| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient]| WEIGHT GAIN
Tricyclic Antidepressant [EPC]| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Inhibitor [EPC]| WEIGHT GAIN
Typical Antipsychotic [EPC]| WEIGHT GAIN
Histamine H2 Receptor Antagonists [MoA],Histamine-2 Receptor Antagonist [EPC]| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],HMG-CoA Reductase Inhibitor [EPC],Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]| WEIGHT GAIN
Anti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE],Cytochrome P450 1A2 Inducers [MoA],Cytochrome P450 2B6 Inducers [MoA],Cytochrome P450 2C8 Inducers [MoA],Cytochrome P450 2C19 Inducers [MoA],Cytochrome P450| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC],Anticholinergic [EPC],Cholinergic Antagonists [MoA]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Depigmenting Activity [PE],Melanin Synthesis Inhibitor [EPC],Melanin Synthesis Inhibitors [MoA],Retinoid [EPC],Retinoids [Chemical/Ingredient]| WEIGHT GAIN
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC],Increased Diuresis [PE],Thiazide-like Diuretic [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Standardized Chemical Allergen [EPC],Increased Histamine Release [PE],Cell-mediated Immunity [PE],Allergens [Chemical/Ingredient]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],Tricyclic Antidepressant [EPC]| WEIGHT GAIN
Benzodiazepine [EPC],Benzodiazepines [Chemical/Ingredient],Tricyclic Antidepressant [EPC]| WEIGHT GAIN
Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Calcium Channel Antagonists [MoA],Decreased Blood Pressure [PE]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],alpha-1 Adrenergic Agonist [EPC],Adrenergic alpha1-Agonists [MoA]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],alpha-1 Adrenergic Agonist [EPC],Adrenergic alpha1-Agonists [MoA],Full Opioid Agonists [MoA],Opioid Agonist [EPC]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC],Sigma-1 Agonist [EPC],Uncompetitive NMDA Receptor Antagonists [MoA],Sigma-1 Receptor Agonists [MoA]| WEIGHT GAIN
Opioid Agonist [EPC],Opioid Agonists [MoA],Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC],Adrenergic alpha-Agonists [MoA],alpha-Adrenergic Agonist [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Aminoglycoside Antibacterial [EPC],Aminoglycosides [Chemical/Ingredient],Polymyxin-class Antibacterial [EPC],Polymyxins [Chemical/Ingredient]| WEIGHT GAIN
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC],Carbonic Anhydrase Inhibitor [EPC],Carbonic Anhydrase Inhibitors [MoA]| WEIGHT GAIN
Full Opioid Agonists [MoA],Opioid Agonist [EPC],Barbiturate [EPC],Barbiturates [Chemical/Ingredient],Central Nervous System Stimulant [EPC],Central Nervous System Stimulation [PE],Methylxanthine [EPC],Xanthines [Chemical/Ingredient]| WEIGHT GAIN
Vitamin D [Chemical/Ingredient],Vitamin D Analog [EPC],Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]| WEIGHT GAIN
Cyclooxygenase Inhibitors [MoA],Decreased Prostaglandin Production [PE],Nonsteroidal Anti-inflammatory Compounds [Chemical/Ingredient],Nonsteroidal Anti-inflammatory Drug [EPC],Barbiturate [EPC],Barbiturates [Chemical/Ingredient],Central Nervous System St| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Azole Antifungal [EPC],Azoles [Chemical/Ingredient]| WEIGHT GAIN
Increased Diuresis [PE],Thiazide-like Diuretic [EPC],Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient],Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines| WEIGHT GAIN
Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient],Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 R| WEIGHT GAIN
Full Opioid Agonists [MoA],Opioid Agonist [EPC],Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient]| WEIGHT GAIN
N-Calcium Channel Receptor Antagonists [MoA],N-type Calcium Channel Antagonist [EPC]| WEIGHT GAIN
Angiotensin Converting Enzyme Inhibitor [EPC],Angiotensin-converting Enzyme Inhibitors [MoA],Decreased Blood Pressure [PE],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Aminoglycoside Antibacterial [EPC],Aminoglycosides [Chemical/Ingredient]| WEIGHT GAIN
Histamine-1 Receptor Antagonist [EPC]| WEIGHT GAIN
Peroxisome Proliferator Receptor gamma Agonist [EPC],Peroxisome Proliferator-activated Receptor Activity [MoA],PPAR gamma [Chemical/Ingredient],Thiazolidinedione [EPC],Thiazolidinediones [Chemical/Ingredient]| WEIGHT GAIN
Peroxisome Proliferator Receptor gamma Agonist [EPC],Peroxisome Proliferator-activated Receptor Activity [MoA],PPAR gamma [Chemical/Ingredient],Thiazolidinedione [EPC],Thiazolidinediones [Chemical/Ingredient],Biguanide [EPC],Biguanides [Chemical/Ingredien| WEIGHT GAIN
Peroxisome Proliferator Receptor gamma Agonist [EPC],Peroxisome Proliferator-activated Receptor Activity [MoA],PPAR gamma [Chemical/Ingredient],Thiazolidinedione [EPC],Thiazolidinediones [Chemical/Ingredient],Sulfonylurea [EPC],Sulfonylurea Compounds [Che| WEIGHT GAIN
Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient],Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]| WEIGHT GAIN
Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC],Sigma-1 Agonist [EPC],Uncompetitive NMDA Receptor Antagonists [MoA],Sigma-1 Receptor Agonists [MoA],Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient]| WEIGHT GAIN
Full Opioid Agonists [MoA],Opioid Agonist [EPC],Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],alpha-1 Adrenergic Agonist [EPC],Adrenergic alpha1-Agonists [MoA]| WEIGHT GAIN
Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA],Inhibition Gastric Acid Secretion [PE]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient]| WEIGHT GAIN
Barbiturate [EPC],Barbiturates [Chemical/Ingredient]| WEIGHT GAIN
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient]| WEIGHT GAIN
Phenothiazine [EPC],Phenothiazines [Chemical/Ingredient],Full Opioid Agonists [MoA],Opioid Agonist [EPC]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Corticosteroid Hormone Receptor Agonists [MoA],Adrenergic beta2-Agonists [MoA],beta2-Adrenergic Agonist [EPC]| WEIGHT GAIN
Sulfonylurea [EPC],Sulfonylurea Compounds [Chemical/Ingredient],Biguanide [EPC],Biguanides [Chemical/Ingredient]| WEIGHT GAIN
Serotonin Reuptake Inhibitor [EPC]| WEIGHT GAIN
Peroxisome Proliferator Receptor alpha Agonist [EPC],Peroxisome Proliferator Receptor gamma Agonist [EPC],Peroxisome Proliferator-activated Receptor Activity [MoA],PPAR alpha [Chemical/Ingredient],PPAR gamma [Chemical/Ingredient],Thiazolidinedione [EPC],T| WEIGHT GAIN
Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA],Cytochrome P450 2C19 Inhibitors [MoA]| WEIGHT GAIN
Cyclooxygenase Inhibitors [MoA],Nonsteroidal Anti-inflammatory Compounds [Chemical/Ingredient],Nonsteroidal Anti-inflammatory Drug [EPC],Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA],Cytochrome P450 2C19 Inhibitors [MoA]| WEIGHT GAIN
Benzodiazepine [EPC],Benzodiazepines [Chemical/Ingredient],Anticholinergic [EPC],Decreased Parasympathetic Acetylcholine Activity [PE],GI Motility Alteration [PE],Digestive/GI System Activity Alteration [PE],Cholinergic Antagonists [MoA]| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC],alpha-1 Adrenergic Agonist [EPC],Adrenergic alpha1-Agonists [MoA]| WEIGHT GAIN
Histamine H1 Receptor Antagonists [MoA],Histamine-1 Receptor Antagonist [EPC],Anticholinergic [EPC],Cholinergic Antagonists [MoA],Adrenergic alpha-Agonists [MoA],alpha-Adrenergic Agonist [EPC]| WEIGHT GAIN
Biguanide [EPC],Biguanides [Chemical/Ingredient],Sulfonylurea [EPC],Sulfonylurea Compounds [Chemical/Ingredient]| WEIGHT GAIN
Angiotensin Converting Enzyme Inhibitor [EPC],Angiotensin-converting Enzyme Inhibitors [MoA],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Blood Coagulation Factor [EPC],Increased Coagulation Factor Activity [PE],Calcium [Chemical/Ingredient],Cations, Divalent [Chemical/Ingredient]| WEIGHT GAIN
Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA],Adrenergic alpha-Agonists [MoA],Adrenergic beta-Agonists [MoA],alpha-Adrenergic Agonist [EPC],beta-Adrenergic Agonist [EPC],Catecholamine [EPC],Catecholamines [Chemical/Ingredient],Adreno| WEIGHT GAIN
Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [Chemical/Ingredient],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines| WEIGHT GAIN
Standardized Chemical Allergen [EPC],Increased Histamine Release [PE],Cell-mediated Immunity [PE],Allergens [Chemical/Ingredient],Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]| WEIGHT GAIN
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC],Anticholinergic [EPC],Cholinergic Antagonists [MoA]| WEIGHT GAIN
Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [Chemical/Ingredient],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides| WEIGHT GAIN
Benzodiazepine [EPC],Benzodiazepines [Chemical/Ingredient],Cytochrome P450 2D6 Inhibitors [MoA]| WEIGHT GAIN
Remeron| WEIGHT GAIN
Eszopiclone| WEIGHT GAIN
Prednisone|MASSIVE WEIGHT GAIN
Lyrica| WEIGHT GAIN
β1 receptor blocker and nitric oxide-potentiator| WEIGHT GAIN